I think I'd like to do a Spider-Girl TV series. Spidey himself would be cool as well of course, but I don't know, I think Spider-Girl would be more interesting, because you could still have Spidey as a character, while focussing on one that leaves the writers more freedom to play with.
You could have May realizing the legacy she comes from, the interactions between her normal life and her superhero life...Focus on this young girl who's learned all about responsibility at the feet of the master (aka her dad*g*)
As for the main roles...
Kay Panabaker. (the girl who plays Daphne on No Ordinary Family), I love her. You'd have to convince her to cut her hair though.