Peter Parker/Tony Stark.
I know, slash pairings like these would never happen, but damnit, Tony was so Peter's sugardaddy/big brother all in one, that I would love to see them together again.
Xander Harris/Andrew Wells
Even if only to show that the Buffy s8 comic can give us naked boys sleeping together, as well as naked girls
Because it brings my two fave pairings, Buffy/Spike and Spike/Angel together and might actually succeed in making all three of them happy.
Because those still have the same chemistry that they did back when I first saw them together.
May Parker(Spider-Girl)/Jake Grimm
Even if only to see Peter's reaction when he finds out his daughter is dating Ben Grimm's son.